LCE Research
Clinical Research
The Lupus Center of Excellence is currently involved in several clinical research studies and clinical research trials. These studies are aimed at understanding premature heart disease in lupus patients, diagnosing lupus and monitoring disease activity, and evaluating new therapies for the treatment of lupus. If you are interested in hearing more about our research or may be interested in participating in a clinical study, please contact us at 412-648-9413 or luceinfo@pitt.edu.
Ongoing Research Projects Include:
University of Pittsburgh Lupus Center of Excellence Patient Registry
The purpose of this registry is to identify lupus patients who are interested in hearing about current and future research studies in which they may be eligible to participate. As a member of the registry, patients will have the opportunity to learn about autoimmune disease research projects being conducted at the Center. Interested patients may participate in studies for which they are deemed eligible.
Molecular Genetics Analysis of Apolipoprotein H in Systemic Lupus Erythematosus.
This study is a collaborative effort between Dr. Ilyas Kamboh, a molecular geneticist, and Dr. Manzi, a clinician/epidemiologist, to examine how APOH genetic variations predict occurrence of antiphospholipid antibodies and thrombotic events in SLE patients.
SLICC: The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis and Neuropsychiatric Disease in Systemic Lupus Erythematosus.
The purpose of this international study involving 10 countries is to determine the frequency of and risk factors for developing vascular disease and neuropsychiatric disease in patients with early lupus (diagnosed with lupus for 18 months or less). To date, more than 500 lupus patients have been enrolled.
Complement Receptor-Ligand Assays for Determination of Diagnosis and Disease Activity in Patients with Inflammatory, Immune-Mediated, and Hematologic Disorders.
This research study is designed to examine new investigational laboratory markers of activity in inflammatory and autoimmune conditions. Disease activity in lupus has been associated with activation (breakdown) of complement (blood proteins) and deposition of the breakdown proteins on blood cells.
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